Cancers of the ovary and fallopian tube together account for most deaths resulting from cancer of the female genital tract. This statistic relates primarily to the fact that, unlike other common malignant gynecologic neoplasms (cancers of the endometrium and cervix), cancers of the ovary and fallopian tube are first seen at relatively advanced stages of disease because of the lack of an effective early diagnostic test. Ovarian cancers are far more common than tubal malignancies and provide most of the data on which the management of both malignancies is based. This chapter first addresses cancers of the ovary extensively, followed by a discussion of cancers of the fallopian tube.