MicroRNA therapeutics in preclinical cancer models
Minlee Kim, Andrea L Kasinski, Frank J Slack
20110301
2011 Apr 1
Lancet Oncol
MicroRNA therapeutics in preclinical cancer models
Lancet Oncol. 2011 Apr;12(4):319-321, Minlee Kim, Andrea L Kasinski, Frank J Slack
Abstract
Substantial progress has been made in the past decade that links the expression of various microRNAs (miRNAs) with cancer. Despite their small sizes at about 22 nucleotides, these endogenous non-coding RNAs have an enormous effect on protein-coding-gene expression, and regulate various cellular events including proliferation, apoptosis, and differentiation. As would be expected, aberrant miRNA expression can have adverse effects on these processes, ultimately contributing to tumour initiation, promotion,...