MicroRNA therapeutics in preclinical cancer models

Lancet Oncol. 2011 Apr;12(4):319-321, Minlee Kim, Andrea L Kasinski, Frank J Slack

Abstract

Substantial progress has been made in the past decade that links the expression of various microRNAs (miRNAs) with cancer. Despite their small sizes at about 22 nucleotides, these endogenous non-coding RNAs have an enormous effect on protein-coding-gene expression, and regulate various cellular events including proliferation, apoptosis, and differentiation. As would be expected, aberrant miRNA expression can have adverse effects on these processes, ultimately contributing to tumour initiation, promotion,...

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