Pathogenesis of Cancer-Induced CachexiaCurrent scientific research implicates an inflammatory reaction to tumor that is predominantly local, but may also be systemic, as the basis for CIC. On a molecular level, proinflammatory cytokines, including interleukins (IL) -1.2 and -6, interferon γ, and TNF-α, have been implicated in initiating a cascade of protein interactions that ultimately result in anorexia and catabolic processes, such as muscle proteolysis and lipolysis.9 Reduced muscle protein synthesis...