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2-cm Versus 4-cm Surgical Excision Margins For Primary Cutaneous Melanoma Thicker Than 2 mm: A Randomised, Multicentre Trial
2-cm Resection Margin Found Adequate in Stage IIA—C Melanoma
P Gillgren, KT Drzewiecki, M Niin, HP Gullestad, H Hellborg, E Mansson-Brahme, C Ingvar, U Ringborg
20111005
2011 Nov 5
Lancet
2-cm Versus 4-cm Surgical Excision Margins For Primary Cutaneous Melanoma Thicker Than 2 mm: A Randomised, Multicentre Trial
Lancet. 2011 Nov 5;378(9803):1635-1642, P Gillgren, KT Drzewiecki, M Niin, HP Gullestad, H Hellborg, E Mansson-Brahme, C Ingvar, U Ringborg
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Abstract
Abstract
Background: Optimum surgical resection margins for patients with clinical stage IIA—C cutaneous melanoma thicker than 2 mm are controversial. The aim of the study was to test whether survival was different for a wide local excision margin of 2 cm compared with a 4-cm excision margin.Methods: We undertook a randomised controlled trial in nine European centres. Patients with cutaneous melanoma thicker than 2 mm, at clinical stage IIA—C, were allocated to have either a 2-cm or a 4-cm surgical resection...
