Adjuvant PEFG (Cisplatin, Epirubicin, 5-Fluorouracil, Gemcitabine) or Gemcitabine Followed by Chemoradiation in Pancreatic Cancer: A Randomized Phase II Trial

Ann Surg Oncol. 2012 Jan 12;[Epub Ahead of Print], JM Reni, G Balzano, G Aprile, E Villa, et al

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Abstract

Abstract

Background: Information from randomized trials on the role of combination chemotherapy in the adjuvant treatment of pancreatic adenocarcinoma is limited. This randomized phase II trial aimed to identify the most promising regimen warranting phase III evaluation.Methods: Therapy-naive patients, age 18-75 years, Karnofsky Performance Status (KPS) >60, gross total resection of stage IB-III pancreatic adenocarcinoma, stratified for center and surgical margins, were randomly assigned to receive either...

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