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Anthracycline-Related Cardiomyopathy After Childhood Cancer: Role of Polymorphisms in Carbonyl Reductase Genes—A Report From the Children's Oncology Group
Genetics May Play Role in Anthracycline-Induced Cardiomyopathy
JG Blanco, C-L Sun, W Landier, L Chen, D Esparza-Duran, W Leisenring, A Mays, DL Friedman, JP Ginsberg, MM Hudson, JP Neglia, KC Oeffinger, AK Ritchey, D Villaluna, MV Relling, S Bhatia
Yes
20111028
2011 Nov 28
J Clin Oncol
Anthracycline-Related Cardiomyopathy After Childhood Cancer: Role of Polymorphisms in Carbonyl Reductase Genes—A Report From the Children's Oncology Group
J Clin Oncol. 2011 Nov 28;[Epub Ahead of Print], JG Blanco, C-L Sun, W Landier, L Chen, D Esparza-Duran, W Leisenring, A Mays, DL Friedman, JP Ginsberg, MM Hudson, JP Neglia, KC Oeffinger, AK Ritchey, D Villaluna, MV Relling, S Bhatia
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Abstract
SUMMARY
OncologySTAT Editorial Team
Anthracyclines are an essential part of many treatments for childhood cancer, but cardiotoxicity develops in up to 60% of patients receiving high doses. Even low doses lead to cardiomyopathy in some patients, suggesting that genetic variability may play a role.Development of cardiomyopathy in patients receiving anthracyclines correlates with myocardial accumulation of anthracycline alcohol metabolites. Thus, variability in the formation of these metabolites could affect cardiomyopathy risk. Synthesis...
