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Biochemical and Imaging Surveillance in Germline TP53 Mutation Carriers With Li-Fraumeni Syndrome: A Prospective Observational Study
Surveillance of TP53 Mutation Carriers With Li-Fraumeni Syndrome
A Villani, U Tabori, J Schiffman, A Shlien, J Beyene, H Druker, A Novokmet, J Finlay, D Malkin
20110501
2011 Jun 1
Lancet Oncol
Biochemical and Imaging Surveillance in Germline TP53 Mutation Carriers With Li-Fraumeni Syndrome: A Prospective Observational Study
Lancet Oncol. 2011 Jun 1;12(6):559-567, A Villani, U Tabori, J Schiffman, A Shlien, J Beyene, H Druker, A Novokmet, J Finlay, D Malkin
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Abstract
Abstract
Background: Individuals with Li-Fraumeni syndrome have a high lifetime risk of developing cancer. We assessed the feasibility and potential clinical effect of a comprehensive surveillance protocol in asymptomatic TP53 mutation carriers in families with this syndrome. Methods: We implemented a clinical surveillance protocol, using frequent biochemical and imaging studies, for asymptomatic TP53 mutation carriers on Jan 1, 2004, and did a prospective observational study of members of eight families...
