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Chemotherapy-Induced Neutropenia in Lung Cancer Patients: The Role of Antibiotic Prophylaxis
Antibiotic Prophylaxis for Neutropenia in Lung Cancer
V Kouranos, G Dimopoulos, A Vassias, KN Syrigos
20110801
2011 Sept 1
Cancer Lett
Chemotherapy-Induced Neutropenia in Lung Cancer Patients: The Role of Antibiotic Prophylaxis
Cancer Lett. 2011 Sept 1;In Press, Accepted Manuscript, V Kouranos, G Dimopoulos, A Vassias, KN Syrigos
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Abstract
Abstract
Chemotherapy-induced neutropenia can cause fatal bacterial infections. Colony-stimulating factors (CSFs) are usually recommended as prophylaxis, while routine use of prophylactic antibiotics remains controversial. Based on our literature search in PubMed, quinolones and trimethoprim/sulfamethoxazole were the most frequently used prophylaxis, while CSFs were administered in 22.1% of patients. Lung cancer patients who received prophylactic antibiotics exhibited significantly fewer episodes of febrile...
