Journal Scans
Chromosome Aberrations Detected by Conventional Karyotyping Using Novel Mitogens in Chronic Lymphocytic Leukemia With "Normal" FISH: Correlations With Clinicobiological Parameters
Cytogenetics Detects CLL Chromosome Abnormalities Missed by FISH
GM Rigolin, F Cibien, S Martinelli, A Cuneo, et al
20120013
2012 Jan 13
Blood
Chromosome Aberrations Detected by Conventional Karyotyping Using Novel Mitogens in Chronic Lymphocytic Leukemia With "Normal" FISH: Correlations With Clinicobiological Parameters
Blood. 2012 Jan 13;[Epub Ahead of Print], GM Rigolin, F Cibien, S Martinelli, A Cuneo, et al
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Abstract
Abstract
It is unclear whether karyotype aberrations occurring in regions uncovered by the standard fluorescence in situ hybridization (FISH) panel have prognostic relevance in chronic lymphocytic leukemia (CLL). We evaluated the significance of karyotypic aberrations in a learning cohort (LC, n=64) and in a validation cohort (VC, n=84) of CLL with "normal" FISH. An abnormal karyotype was found in 21.5% and 35.7% of cases in the LC and VC, respectively, and was associated with lower immunophenotypic score...
