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Clomiphene as a Novel Modality for the Treatment of Acute Myeloid Leukemia: A Pilot Phase II Study
Clomiphene as a Novel Modality for Treatment of AML
G Yom-Tov, I Nathan, O Shpilberg, A Polliack, I Levi
20120001
2012 Jan 1
Leuk Res
Clomiphene as a Novel Modality for the Treatment of Acute Myeloid Leukemia: A Pilot Phase II Study
Leuk Res. 2012 Jan 1;36(1):42-45, G Yom-Tov, I Nathan, O Shpilberg, A Polliack, I Levi
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Abstract
Abstract
Clomiphene, an antiestrogen clinically used for ovulation induction, kills leukemic cells ex vivo via apoptosis. This study was designed to evaluate the antileukemic effect of clomiphene in patients with AML. Eleven patients with recurrent or chemoresistant AML aged 54-79 years received oral clomiphene (25-50mg per day), for seven consecutive days per cycle, up to three cycles while concurrent non intravenous chemotherapy was continued. Ten patients showed a partial response or remained stable during...
