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Combined Androgen Deprivation Therapy and Radiation Therapy for Locally Advanced Prostate Cancer: A Randomised, Phase 3 Trial
Combined ADT and RT for Locally Advanced Prostate Cancer
P Warde, M Mason, K Ding, W Parulekar, et al
20111002
2011 Nov 2
Lancet
Combined Androgen Deprivation Therapy and Radiation Therapy for Locally Advanced Prostate Cancer: A Randomised, Phase 3 Trial
Lancet. 2011 Nov 2;[Epub Ahead of Print], P Warde, M Mason, K Ding, W Parulekar, et al
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Abstract
Abstract
Background: Whether the addition of radiation therapy (RT) improves overall survival in men with locally advanced prostate cancer managed with androgen deprivation therapy (ADT) is unclear. Our aim was to compare outcomes in such patients with locally advanced prostate cancer.Methods: Patients with: locally advanced (T3 or T4) prostate cancer (n=1057); or organ-confined disease (T2) with either a prostate-specific antigen (PSA) concentration more than 40 ng/mL (n=119) or PSA concentration more than...
