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Comparative Effectiveness of Cisplatin-Based and carboplatin-Based Chemotherapy for Treatment of Advanced Urothelial Carcinoma
In Advanced Urothelial Cancer, Cisplatin Better Than Carboplatin
MD Galsky, GJ Chen, WK Oh, J Bellmunt, BJ Roth, R Petrioli, L Dogliotti, R Dreicer, G Sonpavde
20110404
2011 May 4
Ann Oncol
Comparative Effectiveness of Cisplatin-Based and carboplatin-Based Chemotherapy for Treatment of Advanced Urothelial Carcinoma
Ann Oncol. 2011 May 4;[Epub Ahead of Print], MD Galsky, GJ Chen, WK Oh, J Bellmunt, BJ Roth, R Petrioli, L Dogliotti, R Dreicer, G Sonpavde
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Abstract
SUMMARY
OncologySTAT Editorial Team
Cisplatin-based chemotherapy is the standard of care for metastatic urothelial cancer, with carboplatin substituted in patients who are cisplatin ineligible due to impaired renal function and other comorbidities. Since there are no comparative clinical phase III trials of cisplatin vs carboplatin in this setting, Galsky et al conducted a meta-analysis of published randomized trials. Studies were drawn from PubMed citations from 1966 to 2010 and from abstracts presented at the American Society of...
