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Conventional-Dose Versus High-Dose Chemotherapy As First Salvage Treatment in Male Patients With Metastatic Germ Cell Tumors: Evidence From a Large International Database
Defining Optimal Salvage Treatment for Germ Cell Tumors
A Lorch, C Bascoul-Mollevi, A Kramar, L Einhorn, A Necchi, C Massard, U De Giorgi, A Fléchon, K Margolin, JP Lotz, JR Germà-Lluch, T Powles, C Kollmannsberger, J Beyer
20110228
2011 Mar 28
J Clin Oncol
Conventional-Dose Versus High-Dose Chemotherapy As First Salvage Treatment in Male Patients With Metastatic Germ Cell Tumors: Evidence From a Large International Database
J Clin Oncol. 2011 Mar 28;[Epub Ahead of Print], A Lorch, C Bascoul-Mollevi, A Kramar, L Einhorn, A Necchi, C Massard, U De Giorgi, A Fléchon, K Margolin, JP Lotz, JR Germà-Lluch, T Powles, C Kollmannsberger, J Beyer
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Abstract
SUMMARY
OncologySTAT Editorial Team
To date, only one phase III trial has directly compared conventional-dose chemotherapy (CDCT) with high-dose chemotherapy (HDCT) for salvage treatment of patients with metastatic germ cell tumors (GCTs) who experience progression on first-line chemotherapy. The trial found no benefit from HDCT, but methodologic problems in the study have raised questions about the validity of the results. To shed light on whether modality of salvage treatment may impact survival rates in patients with relapsed or...
