Journal Scans
Discontinuation of Proton Pump Inhibitors During Assessment of Chromogranin A Levels in Patients With Neuroendocrine Tumours
CgA Levels Skewed by PPIs in Neuroendocrine Tumors
CM Korse, M Muller, BG Taal
20110911
2011 Oct 11
Br J Cancer
Discontinuation of Proton Pump Inhibitors During Assessment of Chromogranin A Levels in Patients With Neuroendocrine Tumours
Br J Cancer. 2011 Oct 11;105(8):1173-1175, CM Korse, M Muller, BG Taal
TAKE-HOME MESSAGE
Abstract
Abstract
Background: The aim of this prospective study was to examine whether discontinuation of proton pump inhibitors (PPIs) or replacement by H2-receptor antagonists (H2RA) resulted in a decrease of chromogranin A (CgA) levels in 196 patients with well-differentiated neuroendocrine tumours (NETs).Methods: Patients with an unexpectedly high CgA level not connected with NET disease discontinued PPIs, or used H2RA instead; 2 weeks later the CgA level was measured again.Results: In all, 19 out of 196 (10%)...
