Effect of Daily Aspirin on Long-Term Risk of Death Due to Cancer: Analysis of Individual Patient Data From Randomised Trials

Lancet. 2010 Dec 7;[Epub Ahead of Print], PM Rothwell, F Gerald, R Fowkes, JFF Belch, H Ogawa, CP Warlowe, TW Meade

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Abstract

Abstract

Background: Treatment with daily aspirin for 5 years or longer reduces subsequent risk of colorectal cancer. Several lines of evidence suggest that aspirin might also reduce risk of other cancers, particularly of the gastrointestinal tract, but proof in man is lacking. We studied deaths due to cancer during and after randomised trials of daily aspirin versus control done originally for prevention of vascular events. Methods: We used individual patient data from all randomised trials of daily aspirin...

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