Journal Scans
Effectiveness of High Dose Methotrexate in T-cell Lymphoblastic Leukemia and Advanced Stage Lymphoblastic Lymphoma: A Randomized Study by the Children's Oncology Group (POG 9404)
High-Dose Methotrexate Effective in Pediatric T-Cell Acute Lymphoblastic Leukemia
BL Asselin, M Devidas, C Wang, J Pullen, MJ Borowitz, R Hutchison, SE Lipshultz, BM Camitta
20110307
2011 Apr 7
Blood
Effectiveness of High Dose Methotrexate in T-cell Lymphoblastic Leukemia and Advanced Stage Lymphoblastic Lymphoma: A Randomized Study by the Children's Oncology Group (POG 9404)
Blood. 2011 Apr 7;[Epub Ahead of Print], BL Asselin, M Devidas, C Wang, J Pullen, MJ Borowitz, R Hutchison, SE Lipshultz, BM Camitta
TAKE-HOME MESSAGE
Abstract
Abstract
The Pediatric Oncology Group (POG) phase III trial 9404 was designed to determine the effectiveness of high dose methotrexate (HDM) when added to multi-agent chemotherapy based on the Dana-Farber backbone. Children with T-cell acute lymphoblastic leukemia (T-ALL) or advanced lymphoblastic lymphoma (T-NHL) were randomized at diagnosis to receive/not receive HDM (5 g/m2 as a 24-hour infusion) at weeks 4, 7, 10 and 13. Between 1996 and 2000, 436 patients were enrolled in the methotrexate randomization....
