Journal Scans
Eight Cycles of Escalated-Dose BEACOPP Compared With Four Cycles of Escalated-Dose BEACOPP Followed by Four Cycles of Baseline-Dose BEACOPP With or Without Radiotherapy in Patients With Advanced-Stage Hodgkin's Lymphoma
Alternative Strategies for Advanced Hodgkin's Lymphoma Are Needed
P Borchmann, H Haverkamp, V Diehl, T Cerny, J Markova, AD Ho, H-T Eich, HK Mueller-Hermelink, L Kanz, R Greil, A Rank, U Paulus, L Smardova, C Huber, B Dörken, C Nerl, SW Krause, R-P Mueller, M Fuchs, A Engert
20110911
2011 Oct 11
J Clin Oncol
Eight Cycles of Escalated-Dose BEACOPP Compared With Four Cycles of Escalated-Dose BEACOPP Followed by Four Cycles of Baseline-Dose BEACOPP With or Without Radiotherapy in Patients With Advanced-Stage Hodgkin's Lymphoma
J Clin Oncol. 2011 Oct 11;[Epub Ahead of Print], P Borchmann, H Haverkamp, V Diehl, T Cerny, J Markova, AD Ho, H-T Eich, HK Mueller-Hermelink, L Kanz, R Greil, A Rank, U Paulus, L Smardova, C Huber, B Dörken, C Nerl, SW Krause, R-P Mueller, M Fuchs, A Engert
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Abstract
SUMMARY
OncologySTAT Editorial Team
Hodgkin's lymphoma (HL) has become curable for the majority of patients, but there remains a need to improve outcomes for patients with advanced-stage disease. To explore this need, a dose-dense BEACOPP regimen, consisting of bleomycin, etoposide, doxorubicin, cyclophosphamide, vincristine, procarbazine, and prednisone, has been evaluated in a baseline and a dose-escalated version. However, the challenge remains to reduce treatment-related toxicity associated with escalated-dose BEACOPP (BEACOPPescalated)...
