Electromotive Instillation of Mitomycin Immediately Before Transurethral Resection for Patients With Primary Urothelial Non-Muscle Invasive Bladder Cancer: A Randomised Controlled Trial

Lancet Oncol. 2011 Sept 1;12(9):871-879, SM Di Stasi, M Valenti, C Verri, E Liberati, A Giurioli, G Leprini, F Masedu, AR Ricci, F Micali, G Vespasiani

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Abstract

Abstract

Background: The clinical effect of intravesical instillation of chemotherapy immediately after transurethral resection of bladder tumours (TURBT) has recently been questioned, despite its recommendation in guidelines. Our aim was to compare TURBT alone with immediate post-TURBT intravesical passive diffusion (PD) of mitomycin and immediate pre-TURBT intravesical electromotive drug administration (EMDA) of mitomycin in non-muscle invasive bladder cancer.Methods: We did a multicentre, randomised, parallel-group...

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