Journal Scans
Frontline Treatment of Localized Osteosarcoma Without Methotrexate
MTX-Free Regimen Good Alternative in Osteosarcoma
NC Daw, MD Neel, BN Rao, CA Billups, J Wu, JJ Jenkins, J Quintana, L Luchtman-Jones, M Villarroel, VM Santana
20110010
2011 Jan 10
Cancer
Frontline Treatment of Localized Osteosarcoma Without Methotrexate
Cancer. 2011 Jan 10;[Epub Ahead of Print], NC Daw, MD Neel, BN Rao, CA Billups, J Wu, JJ Jenkins, J Quintana, L Luchtman-Jones, M Villarroel, VM Santana
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Abstract
Abstract
Background: The standard treatment of osteosarcoma includes cisplatin and high-dose methotrexate (HDMTX); both agents exert significant toxicity, and HDMTX requires complex pharmacokinetic monitoring and leucovorin rescue. In the previous OS91 trial, the treatment of localized disease with carboplatin, ifosfamide, doxorubicin, and HDMTX yielded outcomes comparable to those of cisplatin-based regimens and caused less toxicity. To build on this experience, the authors conducted a multi-institutional...
