Journal Scans
Gemcitabine and Oxaliplatin With or Without Erlotinib in Advanced Biliary-Tract Cancer: A Multicentre, Open-Label, Randomised, Phase 3 Study
GEMOX +/− Erlotinib in Advanced Biliary Tract Cancer
J Lee, SH Park, HM Chang, HY Lim, et al
20111121
2011 Dec 21
Lancet Oncol
Gemcitabine and Oxaliplatin With or Without Erlotinib in Advanced Biliary-Tract Cancer: A Multicentre, Open-Label, Randomised, Phase 3 Study
Lancet Oncol. 2011 Dec 21;[Epub Ahead of Print], J Lee, SH Park, HM Chang, HY Lim, et al
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Abstract
Abstract
Background: Combination chemotherapy with gemcitabine and a platinum-based agent is regarded as a standard treatment for patients with advanced biliary-tract cancer. Results of phase 2 trials of single-agent erlotinib in biliary-tract cancer and of gemcitabine plus erlotinib in pancreatic cancer have shown modest benefits. Therefore, we aimed to investigate the efficacy of gemcitabine and oxaliplatin plus erlotinib versus chemotherapy alone for advanced biliary-tract cancer.Methods: In this open...
