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Monosomal Karyotype in Primary Myelofibrosis Is Detrimental to Both Overall and Leukemia-Free Survival
Monosomal Karyotype Spells Poor Survival in Primary Myelofibrosis
R Vaidya, D Caramazza, KH Begna, N Gangat, DL Van Dyke, CA Hanson, A Pardanani, A Tefferi
20110230
2011 Mar 30
Blood
Monosomal Karyotype in Primary Myelofibrosis Is Detrimental to Both Overall and Leukemia-Free Survival
Blood. 2011 Mar 30;[Epub Ahead of Print], R Vaidya, D Caramazza, KH Begna, N Gangat, DL Van Dyke, CA Hanson, A Pardanani, A Tefferi
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Abstract
Abstract
Survival in cytogenetically high-risk patients with acute myeloid leukemia or myelodysplastic syndromes is significantly worse in the presence of monosomal karyotype (MK). The objective of the current study was to determine if the same held true for primary myelofibrosis (PMF). Among 793 PMF patients seen at our institution, 62 displayed unfavorable karyotype by way of complex karyotype (n=41) or sole trisomy 8 (n=21). Seventeen (42%) of the 41 patients with complex karyotype were classified as MK....
