Journal Scans
Natural History, Management and Pharmacokinetics of Everolimus-Induced-Oral Ulcers: Insights Into Compliance Issues
Everolimus-Induced Oral Ulcers and Resulting Noncompliance
C Ferte, A Paci, M Zizi, J-C Soria, et al
20110901
2011 Oct 1
Eur J Cancer
Natural History, Management and Pharmacokinetics of Everolimus-Induced-Oral Ulcers: Insights Into Compliance Issues
Eur J Cancer. 2011 Oct 1;47(15):2249-2255, C Ferte, A Paci, M Zizi, J-C Soria, et al
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Abstract
Abstract
Background: Oral Ulcers is a well-recognised adverse event (AE) of mTOR inhibitors. Paradoxically, little is known about its natural history, risk factors, and basic management.Patients and Methods: AEs of 79 patients prospectively enrolled in 6 phase I-II studies testing Everolimus were reviewed. The following parameters were analysed: incidence, severity, duration and associated AE. The association between OU and Everolimus dose, pharmacokinetics and the effectiveness of empiric treatments were...
