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Randomized, Double-Blind, Controlled Trial of Early Endoscopic Ultrasound–Guided Celiac Plexus Neurolysis to Prevent Pain Progression in Patients With Newly Diagnosed, Painful, Inoperable Pancreatic Cancer
Palliative Early EUS-Guided Neurolysis for Inoperable Pancreatic Cancer
JM Wyse, M Carone, SC Paquin, M Usatii, AV Sahai
Yes
20110715
2011 Aug 15
J Clin Oncol
Randomized, Double-Blind, Controlled Trial of Early Endoscopic Ultrasound–Guided Celiac Plexus Neurolysis to Prevent Pain Progression in Patients With Newly Diagnosed, Painful, Inoperable Pancreatic Cancer
J Clin Oncol. 2011 Aug 15;[Epub Ahead of Print], JM Wyse, M Carone, SC Paquin, M Usatii, AV Sahai
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Abstract
SUMMARY
OncologySTAT Editorial Team
Up to 80% of patients with pancreatic cancer have pain at the time of diagnosis. Celiac plexus neurolysis (CPN), which uses alcohol to permanently ablate neural tissue of the celiac ganglia, effectively controls pain in these patients; but, it is generally performed only as a salvage treatment for morphine-resistant pain. Endoscopic ultrasound (EUS), which is commonly used to diagnose and stage pancreatic cancer, can also be used to perform CPN via a transgastric approach. Studies have shown that...
