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Randomized Trials in 2466 Patients With Stage I Seminoma: Patterns of Relapse and Follow-up
Adjuvant Radiation Therapy or Carboplatin for Early Seminoma
GM Mead, SD Fossa, RTD Oliver, JK Joffe, RA Huddart, JT Roberts, P Pollock, R Gabe, SP Stenning
20110116
2011 Feb 16
J Natl Cancer Inst
Randomized Trials in 2466 Patients With Stage I Seminoma: Patterns of Relapse and Follow-up
J Natl Cancer Inst. 2011 Feb 16;103(3):241-249, GM Mead, SD Fossa, RTD Oliver, JK Joffe, RA Huddart, JT Roberts, P Pollock, R Gabe, SP Stenning
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Abstract
SUMMARY
OncologySTAT Editorial Team
Early seminoma is a curable disease, which is treated with one of three modalities (ie, surveillance, radiotherapy, or platinum-based chemotherapy). Approximately 15% to 20% of patients with stage I seminoma will relapse when treated with the surveillance approach. Three randomized noninferiority trials have been conducted in this patient population: TE10 (n = 478), TE18 (n = 625), and TE19 (n = 1477). Two trials evaluated radiotherapy in this setting: TE10 compared the standard “dogleg” field (para-aortic...
