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Risk Factors for Arterial and Venous Thrombosis in WHO-Defined Essential Thrombocythemia: An International Study of 891 Patients
Risk Factors for Thrombosis Identified in Essential Thrombocythemia
A Carobbio, J Thiele, F Passamonti, E Rumi, M Ruggeri, F Rodeghiero, ML Randi, I Bertozzi, AM Vannucchi, E Antonioli, H Gisslinger, V Buxhofer-Ausch, G Finazzi, N Gangat, A Tefferi, T Barbui
20110313
2011 Apr 13
Blood
Risk Factors for Arterial and Venous Thrombosis in WHO-Defined Essential Thrombocythemia: An International Study of 891 Patients
Blood. 2011 Apr 13;[Epub Ahead of Print], A Carobbio, J Thiele, F Passamonti, E Rumi, M Ruggeri, F Rodeghiero, ML Randi, I Bertozzi, AM Vannucchi, E Antonioli, H Gisslinger, V Buxhofer-Ausch, G Finazzi, N Gangat, A Tefferi, T Barbui
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Abstract
Abstract
In an international collaborative study, a central histological review identified 891 patients with essential thrombocythemia (ET), strictly defined by World Health Organization criteria. After a median follow-up of 6.2 years, 109 (12%) patients experienced arterial (n=79) or venous (n=37) thrombosis. In multivariable analysis, predictors of arterial thrombosis included age >60 years (p=0.03; HR 1.7), thrombosis history (p=0.003; HR 2.1), cardiovascular risk factors including tobacco use, hypertension...
