Rituximab Blocks Protective Serological Response to Influenza A(H1N1) 2009 Vaccination in Lymphoma Patients During or Within Six Months After Treatment

Blood. 2011 Nov 8;[Epub Ahead of Print], OE Yri, D Torfoss, O Hungnes, A Kolstad, et al

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Abstract

Abstract

Cancer patients are often encouraged to receive seasonal influenza vaccination. The monoclonal antibody rituximab is widely used in treatment of non-Hodgkin`s lymphoma. This results in a prolonged depletion of normal B cells, which might impair humoral responses. The aim of the present study was to investigate whether lymphoma patients undergoing rituximab-containing treatment regimens or having received such regimens within the last six months were able to mount protective antibody responses to...

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