SUMMARY

OncologySTAT Editorial Team

The molecular mechanisms underlying chemotherapy resistance in patients with colorectal cancer are not well known, but may be related to epigenetic alterations of the gene encoding transcription factor AP-2 epsilon (TFAP2E). The gene encoding dickkopf homolog 4 protein (DKK4) is a possible downstream target of TFAP2E and has been implicated in fluorouracil resistance in patients with colorectal cancer. The current study evaluated the role of TFAP2E in predicting response to chemotherapy in patients...