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The Role of Maintenance Thalidomide Therapy in Multiple Myeloma: MRC Myeloma IX Results and Meta-analysis
Consistent Benefit of Thalidomide Maintenance in Myeloma
GJ Morgan, WM Gregory, FE Davies, SE Bell, AJ Szubert, JM Brown, NN Coy, G Cook, NH Russell, C Rudin, H Roddie, MT Drayson, RG Owen, FM Ross, GH Jackson, JA Child
20110901
2011 Oct 1
Blood
The Role of Maintenance Thalidomide Therapy in Multiple Myeloma: MRC Myeloma IX Results and Meta-analysis
Blood. 2011 Oct 1;October 20, 2011([Epub Ahead of Print]), GJ Morgan, WM Gregory, FE Davies, SE Bell, AJ Szubert, JM Brown, NN Coy, G Cook, NH Russell, C Rudin, H Roddie, MT Drayson, RG Owen, FM Ross, GH Jackson, JA Child
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Abstract
Abstract
Thalidomide maintenance has the potential to modulate residual multiple myeloma (MM) after an initial response. This trial compared the effect of thalidomide maintenance and no maintenance on progression-free survival (PFS) and overall survival (OS) in MM patients. Following intensive or nonintensive induction therapy, 820 newly diagnosed MM patients wererandomized to open-label thalidomide maintenance until progression, or no maintenance. Interphase FISH (iFISH) analysis was performed at study entry....
