Journal Scans
Transient/Reversible Ring Sideroblasts in Bone Marrow of Patients Post Cytotoxic Therapies for Primary Malignancies
Postchemotherapy Ring Sideroblasts as Evidence of Treatment-Related MDS
CY Ok, LJ Medeiros, Hu Y, CE Bueso-Ramos, SA Wang
20111101
2011 Dec 1
Leuk Res
Transient/Reversible Ring Sideroblasts in Bone Marrow of Patients Post Cytotoxic Therapies for Primary Malignancies
Leuk Res. 2011 Dec 1;35(12):1605-1610, CY Ok, LJ Medeiros, Hu Y, CE Bueso-Ramos, SA Wang
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Abstract
Abstract
The diagnosis of therapy-related myelodysplastic syndrome (t-MDS) in the absence of increased myeloblasts or cytogenetic abnormalities is challenging. The presence of ring sideroblasts (RS) in this setting is often used to support the diagnosis of t-MDS. In this study, we reviewed 843 patients initially classified as therapy-related myeloid neoplasm in our hospital over 10 years. Nineteen (2.3%) patients had a normal karyotype, <5% bone marrow (BM) blasts, and ≥15% RS (17–70%), forming this study...
