Abstract

Routine incorporation of fluorescence in situ hybridization (FISH) testing into the multiple myeloma work-up has lead to better appreciation of the heterogeneity of genetic abnormalities in this disease. We studied a group of 484 patients with newly diagnosed symptomatic myeloma in order to better understand the prevalence of the various abnormalities and the prognostic significance of the overlapping abnormalities. A translocation involving the IgH heavy chain locus and one of the five recurrent...