Journal Scans
Vitamin E and the Risk of Prostate Cancer The Selenium and Vitamin E Cancer Prevention Trial (SELECT)
Vitamin E Increases Risk of Prostate Cancer
EA Klein, IM Thompson, CM Tangen, LH Baker, et al
20110912
2011 Oct 12
JAMA
Vitamin E and the Risk of Prostate Cancer The Selenium and Vitamin E Cancer Prevention Trial (SELECT)
JAMA. 2011 Oct 12;306(14):1549-1556, EA Klein, IM Thompson, CM Tangen, LH Baker, et al
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Abstract
SUMMARY
OncologySTAT Editorial Team
Preclinical and epidemiologic evidence suggest that selenium and vitamin E may reduce risk of prostate cancer. The Selenium and Vitamin E Cancer Prevention Trial (SELECT) was a prospective randomized placebo-controlled study evaluating the effect of selenium and vitamin E on prevention of prostate cancer. The trial was discontinued following a preplanned interim analysis that demonstrated no benefit of either agent. Indeed, early follow-up (5.5 years) suggested instead an increased risk of prostate...
