Primary Myelofibrosis: 2012 Update on Diagnosis, Risk Stratification, and Management
2012 Update on Primary Myelofibrosis
A Tefferi
Yes
20111101
2011 Dec 1
Am J Hematol
Yes
Primary Myelofibrosis: 2012 Update on Diagnosis, Risk Stratification, and Management
Am J Hematol. 2011 Dec 1;86(12):1017-1026, A Tefferi
Abstract
Abstract
Disease Overview: Primary myelofibrosis (PMF) is a myeloproliferative neoplasm characterized by stem cell-derived clonal myeloproliferation, abnormal cytokine expression, bone marrow fibrosis, anemia, splenomegaly, extramedullary hematopoiesis (EMH), constitutional symptoms, cachexia, leukemic progression, and shortened survival.Diagnosis: Diagnosis is based on bone marrow morphology. The presence of fibrosis, JAK2/MPL mutation or +9/13q− cytogenetic abnormality is supportive but not essential for...
