Prognostic and Therapeutic Implications of Minimal Residual Disease Detection in Acute Myeloid Leukemia
Prognostic Implications of MRD Detection in AML Risk Assessment
F Buccisano, L Maurillo, MI Del Principe, A Venditti, et al
Yes
20120012
2012 Jan 12
Blood
Yes
Prognostic and Therapeutic Implications of Minimal Residual Disease Detection in Acute Myeloid Leukemia
Blood. 2012 Jan 12;[Epub Ahead of Print], F Buccisano, L Maurillo, MI Del Principe, A Venditti, et al
Abstract
Abstract
The choice of either induction or post-remission therapy for adults with acute myeloid leukemia is still largely based on the "one size fits all" principle. Moreover, pre-treatment prognostic parameters, especially chromosome and gene abnormalities, may fail in predicting individual patient outcome. Measurement of minimal residual disease (MRD) is nowadays recognized as a potential critical tool to assess the quality of response after chemotherapy and to plan post-remission strategies that are, therefore,...
