Impact of HPV status on treatment of squamous cell cancer of the oropharynx: What we know and what we need to know
Silke Tribius, Anna S. Ihloff, Thorsten Rieckmann, Cordula Petersen, Markus Hoffmann
20110401
2011 May 1
Cancer Lett
Impact of HPV status on treatment of squamous cell cancer of the oropharynx: What we know and what we need to know
Cancer Lett. 2011 May 28;304(2):71-79, Silke Tribius, Anna S. Ihloff, Thorsten Rieckmann, Cordula Petersen, Markus Hoffmann
Abstract
Abstract
Studies report an increasing incidence of oropharyngeal cancers linked to infection by human papillomavirus (HPV). We reviewed trials assessing outcomes by HPV DNA status in patients with locally advanced oropharyngeal cancer. Seven of the eight studies identified showed significantly better survival in patients with HPV DNA-positive tumors vs. HPV DNA-negative tumors. The review also describes what needs to be defined regarding optimal treatments. Future trials should incorporate HPV DNA status...
