Abstract

The prognostic factors in adult acute leukemia have undergone a major change over the past decade and are likely to be further refined in the coming years. Age is the single most important prognostic factor in both acute myeloid leukemias and in acute lymphoblastic leukemias. Recurring cytogenetic abnormalities and molecular markers have become crucial for the prognosis of patients and for new directions in the development of targeted therapies. No less important is the development of a personalized...