Treatment Implications of the Emerging Molecular Classification System for Melanoma
Emerging Molecular Classification System for Melanoma Treatment
E Romano, GK Schwartz, PB Chapman, JD Wolchock, RD Carvajal
Yes
20110801
2011 Sept 1
Lancet Oncol
Treatment Implications of the Emerging Molecular Classification System for Melanoma
Lancet Oncol. 2011 Sept 1;12(9):913-922, E Romano, GK Schwartz, PB Chapman, JD Wolchock, RD Carvajal
Abstract
Abstract
Melanoma is an aggressive disease with few standard treatment options. The conventional classification system for this disease is based on histological growth patterns, with division into four subtypes: superficial spreading, lentigo maligna, nodular, and acral lentiginous. Major limitations of this classification system are absence of prognostic importance and little correlation with treatment outcomes. Recent preclinical and clinical findings support the notion that melanoma is not one malignant...
