Circulating Tumour Cells, Their Role in Metastasis and Their Clinical Utility in Lung Cancer
Role of Circulating Tumor Cells in Lung Cancer
JD O'Flaherty, S Gray, JJ O'Leary, FH Blackhall, KJ O'Byrne
Yes
20111129
2011 Dec 29
Lung Cancer
Circulating Tumour Cells, Their Role in Metastasis and Their Clinical Utility in Lung Cancer
Lung Cancer. 2011 Dec 29;[Epub Ahead of Print], JD O'Flaherty, S Gray, JJ O'Leary, FH Blackhall, KJ O'Byrne
Abstract
Abstract
Circulating tumour cells (CTCs) have attracted much recent interest in cancer research as a potential biomarker and as a means of studying the process of metastasis. It has long been understood that metastasis is a hallmark of malignancy, and conceptual theories on the basis of metastasis from the nineteenth century foretold the existence of a tumour "seed" which is capable of establishing discrete tumours in the "soil" of distant organs. This prescient "seed and soil" hypothesis accurately predicted...
