A Decade Of Tyrosine Kinase Inhibitor Therapy: Historical and Current Perspectives on Targeted Therapy for GIST
Historical and Current Perspectives on Targeted Therapy for GIST
J-Y Blay
Yes
20110701
2011 Aug 1
Cancer Treat Rev
A Decade Of Tyrosine Kinase Inhibitor Therapy: Historical and Current Perspectives on Targeted Therapy for GIST
Cancer Treat Rev. 2011 Aug 1;37(5):373-384, J-Y Blay
Abstract
Abstract
The introduction of molecularly targeted therapies has ushered in a considerable transformation in the management of gastrointestinal stromal tumors (GIST) that currently defines the paradigm of targeted therapy for solid tumors. Indeed, in the past decade the management of GIST has evolved from a disease only effectively treatable by surgery to the archetype of a tumor treatable with a molecularly targeted therapy. Better understanding of the molecular and genetic characteristics that underlie the...
