Cancer of unknown primary patients with midline nodal distribution: Midway between poor and favourable prognosis?

Cancer Treat Rev. 2011 Apr;37(2):120-126, George Pentheroudakis, Aikaterini Stoyianni, Nicholas Pavlidis

Abstract

Abstract

BackgroundMidline nodal cancer of unknown primary (CUP) has varying definitions and an unclear natural history compared to that of extragonadal germ cell cancer (EGCC) and neuroendocrine tumors.MethodsWe systematically reviewed all published series of patients with midline nodal CUP using three distinct definitions and presented our own retrospective cohort.ResultsSixty four fit patients (median age 64) with poorly differentiated carcinoma or adenocarcinoma in midline nodal areas were treated from...

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