JOURNAL SCANS: REVIEW

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mTOR Inhibitors in Cancer Therapy

YY Zaytseva, JD Valentino, P Gulhati, BM Evers, 2012 Jun 1, Cancer Lett

Abstract The mammalian target of rapamycin (mTOR) plays a key role in regulation of cellular metabolism, growth, and proliferation. The frequent hyperactivation of mTOR signaling makes it an attractive...

Skeletal Metastases – The Role of the Orthopaedic and Spinal Surgeon

N Eastley, M Newey, RU Ashford, 2012 May 4, Surg Oncol

Abstract Developments in oncological and medical therapies mean that life expectancy of patients with metastatic bone disease (MBD) is often measured in years. Complications of MBD may dramatically and...

Treatment Trends and Outcomes of Small-Cell Carcinoma of the Bladder

EJ Koay, BS Teh, AC Paulino, EB Butler, 2012 May 1, Int J Radiat Oncol Biol Phys

Abstract Purpose: Treatment for small-cell carcinoma of the bladder is largely guided by case reports, retrospective reviews, and small prospective trials. This study aimed to study outcomes using a large...

The Management of Neuroendocrine Tumours: Current and Future Medical Therapy Options

KE Oberg, 2012 May 1, Clin Oncol

Abstract Neuroendocrine tumours (NETs) are a genetically diverse group of malignancies that sometimes produce peptides causing characteristic hormonal syndromes. NETs can be clinically symptomatic (functioning)...

Melanoma Molecular Classes and Prognosis in the Postgenomic Era

E Tremante, A Ginebri, E Lo Monaco, P Frascione, T Di Filippo, I Terrenato, M Benevolo, M Mottolese, E Pescarmona, P Visca, PG Natali, P Giacomini, 2012 May 1, Lancet Oncol

Abstract Gene expression profiling is a powerful method to classify human tumours on the basis of biological aggressiveness, response to therapy, and outcome for the patient, but its application in melanoma...

Mediastinal Staging of Lung Cancer: Novel Concepts

KG Tournoy, SM Keller, JT Annema, 2012 May 1, Lancet Oncol

Abstract Clinical TNM staging is the standard method used to decide treatment for patients with non-small-cell lung cancer. Although integrated fluorodeoxyglucose (FDG) PET CT increases the accuracy of...

Ovarian Low-Grade Serous Carcinoma: A Comprehensive Update

I Diaz-Padilla, AL Malpica, L Minig, LM Chiva, DM Gershenson, A Gonzalez-Martin, 2012 Apr 30, Gynecol Oncol

Abstract Ovarian low-grade serous ovarian carcinoma (OvLGSCa) comprises a minority within the heterogeneous group of ovarian carcinomas. Despite biological differences with their high-grade serous counterparts,...

How Does Preoperative Radiotherapy Affect the Rate of Sphincter-Sparing Surgery in Rectal Cancer?

B Baker, H Salameh, M Al-Salman, F Daoud, 2012 Apr 26, Surg Oncol

Abstract The use of preoperative radiotherapy has resulted in significant downstaging and downsizing of tumor, this in turn facilitated resections permitting sphincter preservation and coloanal anastomosis...

Bisphosphonate-Related Osteonecrosis of the Jaws – A Review

S Kuhl, C Walter, S Acham, R Pfeffer, JT Lambrecht, 2012 Apr 23, Oral Oncol

Abstract The aim was to evaluate the knowledge about bisphosphonate-related osteonecrosis of the jaws (BRONJ). A bibliographic search in Medline, PubMed and the Cochrane Register of controlled clinical...

Primary Lymphoma of the Ocular Adnexa (Orbital Lymphoma) and Primary Intraocular Lymphoma

DK Woolf, M Ahmed, PN Plowman, 2012 Apr 23, Clin Oncol

Abstract Lymphomas of the orbit and eye are rare conditions that should be treated as separate entities due to the differences in presumed aetiology, investigations, management and outcomes. Orbital lymphoma...

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