Phase II Results Continue to Support Carfilzomib in Myeloma

Elsevier Global Medical News. 2012 Jan 17, P Wendling

SAN DIEGO (EGMN) - Adding the investigational protease inhibitor carfilzomib to lenalidomide and low-dose dexamethasone produced responses comparable with those achieved with the best frontline regimens in multiple myeloma, final results from a multicenter phase I/II study indicate.Nearly all, 94%, of 49 evaluable patients with newly diagnosed multiple myeloma achieved at least a partial response with the triple combination, and 53% attained a near complete, complete, or stringent complete response...

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