Researchers using massively parallel sequencing to characterize the spectrum of somatic mutations in chronic lymphocytic leukemia identified nine genes that are mutated at significant frequencies in the disease.Of these nine "driver" genes, which were identified from DNA samples from normal tissues and tumors in 91 patients with chronic lymphocytic leukemia, four have previously established roles in the disease (TP53, ATM, MYD88, and NOTCH1), and five do not (SF3B1, ZMYM3, MAPK1, FBXW7, and DDX3X),...