Whole-Brain Irradiation for Metastatic Disease More Than Doubles Risk of Cognitive Problems Over Radiosurgery Alone

Elsevier Global Medical News. 2008 Sept 24, N Osterweil

BOSTON (EGMN) - Patients with brain metastases treated with both radiosurgery and whole brain irradiation have more than twice the risk of memory and neurocognitive problems and significantly lower median survival than patients treated with radiosurgery alone, results of a phase III randomized trial suggest.The study, which compared stereotactic radiosurgery with or without whole brain irradiation in 58 patients newly diagnosed with one to three brain metastases, showed that those who underwent the...

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