"Ask the Expert” features answers by our experts to your clinical questions. Question: What is the best initial treatment of ER-positive oligometastatic disease: systemic chemotherapy up-front for 6 months, or hormone therapy? What about metastasectomies, including skin lesions?Answer: Ordinarily, for metastatic hormone receptor-positive breast cancer, if it is a local recurrence, we would want to achieve local control. That might be by surgery, with clear margins if possible, and radiation therapy....