"Ask the Expert” features answers by our experts to your clinical questions. Question: What is the ideal management of advanced adult gastric DLBCL?Answer: Typically, an advanced large cell lymphoma in the stomach has acquired independence from Helicobacter pylori, even if the patient is H. pylori–positive; so, these patients require chemotherapy. There have been some data suggesting a more indolent course to this disease, but I would not recommend observation. There are no large studies that are...