"Ask the Expert” features answers by our experts to your clinical questions. Question: How should one use zoledronic acid in a patient with stage IVB diffuse large B-cell lymphoma who has extensive bone involvement at presentation but a complete PET and clinical response after eight cycles of R-CHOP? I am concerned about the long-term consequences of using bisphosphonates in this relatively young man.Answer: This is a controversial issue. Inasmuch as there are data to guide bisphosphonate use in...