Pitfalls in Extrapolating Adult Data to Rare Paediatric Diseases

Lancet Oncol. 2011 Dec 1;12(13):1180-1181, H Traunecker

Abstract

Kotecha and colleagues’ meta-analysis in The Lancet Oncology of individual patient data from children and adolescents with meningioma makes a valuable contribution to the debate surrounding the best clinical management of a rare paediatric brain tumour that is, in fact, a common diagnosis in adults. In the UK, national treatment recommendations for meningioma in adults have been issued, but there are no similar recommendations for children and young adults. In the absence of paediatric trial data,...

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